Genome location: Pf3D7_11_v3:1,289,824..1,292,127(+)
Genome classification: Core
Product Description: cell division control protein CDC50B
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005515 | protein binding |
| Process | GO:0035891 | exit from host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.21 | 0.87 |
| Schizont | expressed | 1.24 | 0.42 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1133300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.087 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0915100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0916600)
Modification: Disrupted | RMgm-4797
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II31
"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=2.43) with 3NTA (Global RMSD=15.71)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 9 | 11 |
| disruptive | 4 | 8 | 11 | 24 |
| missense | 4 | 8 | 9 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 10 | 17 |
| disruptive | 7 | 25 | 24 | 67 |
| missense | 4 | 18 | 20 | 52 |
PlasmoDB Total SNPs: 49
Non-coding: 39 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 366 | Molecular Weight (kDa): 44.148
UniProt ID(s): Q8II31
PDB ID(s): None
Isoelectric Point: 9.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005045 | CDC50/LEM3 family |
| PFam | PF03381 | CDC50/LEM3 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35862778 | CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in MerozoiteEgress and Trophozoite Maturation. | Patel A, Nofal SD, Blackman MJ, Baker DA | 10.1128/mbio.01635-22 |