PF3D7_1133500

Genome location: Pf3D7_11_v3:1,296,801..1,298,199(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.22	0.86
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1133500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -2.827 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0914900)

Relative Growth Rate: 0.11 ± 0.03
Confidence: 8.36

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II30

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.04) with 6A2L (Global RMSD=19.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156404

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	12	4	9
disruptive	5	20	14	45
missense	5	20	14	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	17	8	18
disruptive	11	53	23	73
missense	7	41	21	60

PlasmoDB Total SNPs: 37

Non-coding: 25 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 392 | Molecular Weight (kDa): 48.097

UniProt ID(s): Q8II30

PDB ID(s): None

Isoelectric Point: 9.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A