PF3D7_1133700

Genome location: Pf3D7_11_v3:1,301,308..1,307,797(+)

Genome classification: Core

Function and Localization

Product Description: FHA domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003729	mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.70	0.35
Trophozoite	expressed	0.69	0.64
Schizont	expressed	0.40	0.78
Gametocyte	expressed	0.98	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1133700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.847 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II28

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=3.96) with 8H99 (Global RMSD=28.40)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130923

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	46	20	39
disruptive	31	81	49	141
missense	16	68	39	115

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	85	36	47
disruptive	48	185	109	252
missense	24	137	79	160

PlasmoDB Total SNPs: 313

Non-coding: 225 | Synonymous: 62 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 997 | Molecular Weight (kDa): 120.54

UniProt ID(s): Q8II28

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR008984	SMAD/FHA domain superfamily
InterPro	IPR012816	NADAR
InterPro	IPR035979	RNA-binding domain superfamily
InterPro	IPR037238	YbiA-like superfamily
PFam	PF00498	Forkhead-associated (FHA) domain
Superfamily	SSF143990	YbiA-like superfamily
Superfamily	SSF49879	SMAD/FHA domain superfamily
Superfamily	SSF54928	RNA-binding domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104