About Gene List

PF3D7_1133900

Genome location: Pf3D7_11_v3:1,312,734..1,317,676(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.58 0.72
Trophozoite possibly expressed 0.71 0.61
Schizont possibly expressed 0.34 0.79
Gametocyte not expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1133900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.468 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II26

"Best" AlphaFill ligand hit: CTP (cytidine-5'-triphosphate, Local RMSD=14.21) with 7ECD (Global RMSD=20.51)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533405

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 47 29 54
disruptive 51 131 79 167
missense 44 114 71 149

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 90 44 62
disruptive 80 254 109 224
missense 65 211 89 180

PlasmoDB Total SNPs: 205

Non-coding: 105 | Synonymous: 50 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1231 | Molecular Weight (kDa): 146.344

UniProt ID(s): Q8II26

PDB ID(s): None

Isoelectric Point: 4.55

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104