Genome location: Pf3D7_11_v3:1,322,407..1,325,617(-)
Genome classification: Core
Product Description: protein disulfide-isomerase, putative
SignalP Peptide: MKVYNFSFICISLIFVFIKRSLG
# Transmembrane Domains: 0
EC Numbers: 5.3.4.1 (Protein disulfide-isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005788 | endoplasmic reticulum lumen |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0009055 | electron transfer activity |
| Function | GO:0003756 | protein disulfide isomerase activity |
| Process | GO:0055114 | oxidation-reduction process |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.57 | 0.68 |
| Schizont | expressed | 0.31 | 0.81 |
| Gametocyte | expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1134100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.995 | MFS: -2.894 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II23
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.25) with 3T58 (Global RMSD=2.52)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.3.4.1 | protein disulfide-isomerase | NEM16F16LOC14AsO43-CCF642MA3 018MA3 019acroleinneomycinpeptidesgenisteinkanamycin... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q15084 | Protein disulfide-isomerase A6 | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | CHEMBL4751979 |
Ortholog Group (OrthoMCL): OG6_100473
Most Similar Human Ortholog: Q15084
TM-align score: 0.42 | RMSD: 4.95
Seq Identity: 0.20 | Length: 238 / 423
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143870 | protein disulfide isomerase family A member 6 |
Protein Length: 423 | Molecular Weight (kDa): 49.195
UniProt ID(s): Q8II23
PDB ID(s): None
Isoelectric Point: 9.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00085 | Thioredoxin domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 154
Non-coding: 140 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |