PF3D7_1134200

Genome location: Pf3D7_11_v3:1,326,228..1,332,808(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.38	0.43
Trophozoite	expressed	1.05	0.48
Schizont	expressed	0.25	0.86
Gametocyte	expressed	0.76	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1134200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.16 | MFS: -3.249 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II22

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532792

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	91	58	132
disruptive	39	269	162	352
missense	36	258	160	334

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	170	87	143
disruptive	90	562	213	435
missense	61	519	202	365

PlasmoDB Total SNPs: 197

Non-coding: 30 | Synonymous: 98 | Nonsynonymous: 69 | Stop Codon: 0

Protein Information

Protein Length: 1805 | Molecular Weight (kDa): 214.592

UniProt ID(s): Q8II22

PDB ID(s): None

Isoelectric Point: 9.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A