Genome location: Pf3D7_11_v3:1,333,076..1,340,271(+)
Genome classification: Core
Product Description: erythrocyte membrane and merozoite antigen EMMA1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0009986 | cell surface |
| Component | GO:0044228 | host cell surface |
| Component | GO:0005634 | nucleus |
| Process | GO:0052559 | induction by symbiont of host immune response |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.24 | 0.89 |
| Trophozoite | not expressed | 0.75 | 0.62 |
| Schizont | expressed | 1.16 | 0.49 |
| Gametocyte | possibly expressed | 0.86 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1134300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.442 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0914100)
Modification: Disrupted | RMgm-2549
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II21
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.19) with 7AGJ (Global RMSD=24.92)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 128 | 58 | 136 |
| disruptive | 70 | 400 | 228 | 503 |
| missense | 56 | 387 | 222 | 465 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 225 | 75 | 167 |
| disruptive | 146 | 822 | 335 | 551 |
| missense | 111 | 758 | 308 | 464 |
PlasmoDB Total SNPs: 234
Non-coding: 50 | Synonymous: 86 | Nonsynonymous: 98 | Stop Codon: 0
Protein Length: 2227 | Molecular Weight (kDa): 262.842
UniProt ID(s): Q8II21
PDB ID(s): None
Isoelectric Point: 8.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34342640 | A newly characterized malaria antigen on erythrocyte and merozoite surfacesinduces parasite inhibitory antibodies | Michelow IC, Park S, ..., Kurtis JD | 10.1084/jem.20200170 |