About Gene List

PF3D7_1134400

Genome location: Pf3D7_11_v3:1,340,325..1,342,250(-)

Genome classification: Core

Function and Localization

Product Description: WPP motif-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.03 0.99
Trophozoite possibly expressed 0.24 0.85
Schizont possibly expressed 0.03 0.98
Gametocyte not expressed 0.22 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1134400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.033 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0914000)

  • Relative Growth Rate: 0.06 ± 0.03
  • Confidence: 8.28

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0914000)

Modification: Tagged | RMgm-4970

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II20

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136383

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 1
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 1 0 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 93

Non-coding: 79 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 174 | Molecular Weight (kDa): 20.664

UniProt ID(s): Q8II20

PDB ID(s): None

Isoelectric Point: 10.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21