Product Description: alpha/beta hydrolase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.1.-.- (Acting on ester bonds.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.41 | 0.80 |
| Trophozoite | possibly expressed | 0.92 | 0.52 |
| Schizont | possibly expressed | 0.81 | 0.56 |
| Gametocyte | not expressed | 0.57 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1134500
Resistome Missense Mutations: N1263Y
Resistome Compounds with Missense Mutations: NEU-1029
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.181 | MFS: -3.306 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II19
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.-.- | Ex: 5-phospho-D-xylono-1,4-lactonase | paraoxonatropineethylene terephthalatediisopropyl fluorophosphonatebis(2-hydroxyethyl) terephthalic acidphosphoric acid-bis-4-nitrophenyl ester |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104869
Most Similar Human Ortholog: U3KQG3
TM-align score: 0.59 | RMSD: 2.42
Seq Identity: 0.03 | Length: 37 / 1744
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000122335 | serine active site containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 92 | 42 | 95 |
| disruptive | 46 | 197 | 119 | 271 |
| missense | 41 | 189 | 114 | 244 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 163 | 64 | 126 |
| disruptive | 84 | 444 | 186 | 424 |
| missense | 64 | 381 | 158 | 302 |
PlasmoDB Total SNPs: 233
Non-coding: 95 | Synonymous: 70 | Nonsynonymous: 68 | Stop Codon: 0
Protein Length: 1744 | Molecular Weight (kDa): 210.539
UniProt ID(s): Q8II19
PDB ID(s): None
Isoelectric Point: 10.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012908 | GPI inositol-deacylase PGAP1-like |
| InterPro | IPR029058 | Alpha/Beta hydrolase fold |
| PFam | PF07819 | GPI inositol-deacylase PGAP1-like |
| Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |