Genome location: Pf3D7_11_v3:1,350,158..1,358,171(-)
Genome classification: Core
Product Description: CCCH-type zinc finger protein ZNF4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Process | GO:0051701 | biological process involved in interaction with host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | possibly expressed | 0.21 | 0.89 |
| Schizont | not expressed | 0.13 | 0.92 |
| Gametocyte | expressed | 0.97 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1134600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.522 | #Insertions: 6
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II18
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 116 | 61 | 116 |
| disruptive | 84 | 374 | 212 | 435 |
| missense | 58 | 317 | 190 | 365 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 224 | 77 | 126 |
| disruptive | 175 | 752 | 308 | 561 |
| missense | 113 | 624 | 245 | 362 |
PlasmoDB Total SNPs: 441
Non-coding: 212 | Synonymous: 127 | Nonsynonymous: 102 | Stop Codon: 0
Protein Length: 1722 | Molecular Weight (kDa): 203.986
UniProt ID(s): Q8II18
PDB ID(s): None
Isoelectric Point: 9.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000571 | Zinc finger, CCCH-type |
| InterPro | IPR036855 | Zinc finger, CCCH-type superfamily |
| PFam | PF00642 | Zinc finger, CCCH-type |
| Superfamily | SSF90229 | Zinc finger, CCCH-type superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35626703 | The Plasmodium falciparum C CCH Zinc Finger Protein Z NF4 Plays an Important Rolein Gametocyte Exflagellation through the Regulation of Male Enriched Transcripts | Hanhsen B, Farrukh A, Pradel G, Ngwa CJ | 10.3390/cells11101666 |
| 38148574 | The Plasmodium falciparum CCCH zinc finger protein MD3 regulates malegametocytogenesis through its interaction with RNA-binding proteins | Farrukh A, Musabyimana JP, ..., Ngwa CJ | 10.1111/mmi.15215 |