Product Description: coatomer subunit delta
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030126 | COPI vesicle coat |
| Component | GO:0030137 | COPI-coated vesicle |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Process | GO:0051645 | Golgi localization |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.40 | 0.80 |
| Trophozoite | expressed | 0.49 | 0.70 |
| Schizont | expressed | 0.39 | 0.75 |
| Gametocyte | possibly expressed | 0.51 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1134800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.142 | MFS: -3.396 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0913700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0913700)
Modification: Disrupted | RMgm-2546
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II16
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101729
Most Similar Human Ortholog: P48444
TM-align score: 0.72 | RMSD: 4.77
Seq Identity: 0.19 | Length: 449 / 487
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000095139 | archain 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 9 | 31 |
| disruptive | 3 | 19 | 16 | 34 |
| missense | 3 | 19 | 15 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 49 | 17 | 26 |
| disruptive | 6 | 67 | 34 | 102 |
| missense | 5 | 61 | 24 | 50 |
PlasmoDB Total SNPs: 69
Non-coding: 62 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 487 | Molecular Weight (kDa): 56.84
PDB ID(s): None
Isoelectric Point: 5.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011012 | Longin-like domain superfamily |
| InterPro | IPR027059 | Coatomer delta subunit |
| InterPro | IPR036168 | AP-2 complex subunit mu, C-terminal superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF49447 | AP-2 complex subunit mu, C-terminal superfamily |
| Superfamily | SSF64356 | Longin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12165385 | Characterisation of a delta-COP homologue in the malaria parasite, Plasmodiumfalciparum. | Adisa A, Rug M, Foley M, Tilley L | 10.1016/s0166-6851(02)00117-2 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |