PF3D7_1134900

Genome location: Pf3D7_11_v3:1,369,619..1,371,667(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.06	0.97
Schizont	not expressed	0.13	0.91
Gametocyte	not expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1134900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.157 | MFS: -2.808 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0913600)

Relative Growth Rate: 1.03 ± 0.11
Confidence: 5.81

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0913600)

Modification: Disrupted | RMgm-2545

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II15

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533575

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	22	14	43
disruptive	22	88	57	122
missense	13	78	52	105

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	47	25	43
disruptive	45	196	76	213
missense	29	158	64	149

PlasmoDB Total SNPs: 65

Non-coding: 0 | Synonymous: 32 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 682 | Molecular Weight (kDa): 81.609

UniProt ID(s): Q8II15

PDB ID(s): None

Isoelectric Point: 9.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A