PF3D7_1135000

Genome location: Pf3D7_11_v3:1,371,743..1,374,175(+)

Genome classification: Core

Function and Localization

Product Description: PQ-loop repeat-containing protein

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	possibly expressed	nd	nd
Schizont	possibly expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1135000.3

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.66 | MFS: -2.879 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II14

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102406

Most Similar Human Ortholog: O75352

TM-align score: 0.86 | RMSD: 2.47

Seq Identity: 0.26 | Length: 227 / 233

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000129255	mannose-P-dolichol utilization defect 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	8	23
disruptive	3	6	4	19
missense	3	5	4	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	19	14	19
disruptive	6	22	18	31
missense	4	17	13	22

PlasmoDB Total SNPs: 83

Non-coding: 76 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 233 | Molecular Weight (kDa): 27.188

UniProt ID(s): Q8II14

PDB ID(s): None

Isoelectric Point: 10.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006603	PQ-loop repeat
InterPro	IPR016817	Mannose-P-dolichol utilization defect 1 protein
PFam	PF04193	PQ-loop repeat
Superfamily	N/A	N/A