About Gene List

PF3D7_1135300 (PMRT1)

Genome location: Pf3D7_11_v3:1,380,567..1,382,594(-)

Genome classification: Core

Function and Localization

Product Description: plasma membrane resident transporter 1

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005886 plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.02 0.99
Trophozoite expressed 0.04 0.97
Schizont expressed 0.01 0.99
Gametocyte not expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1135300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.175 | MFS: -2.603 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0913200)

  • Relative Growth Rate: 0.05 ± 0.05
  • Confidence: 7.29

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II12

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532489

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 13 8 23
disruptive 8 24 18 33
missense 7 24 16 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 27 18 24
disruptive 11 73 42 96
missense 9 53 33 52

PlasmoDB Total SNPs: 92

Non-coding: 68 | Synonymous: 15 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 409 | Molecular Weight (kDa): 48.429

UniProt ID(s): Q8II12

PDB ID(s): None

Isoelectric Point: 8.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
35404116 PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essentialfor Asexual and Sexual Blood Stage Development. Wichers JS, Mesen-Ramirez P, ..., Strauss J 10.1128/mbio.00623-22