About Gene List

PF3D7_1135400

Genome location: Pf3D7_11_v3:1,384,340..1,385,924(-)

Genome classification: Core

Function and Localization

Product Description: HotDog domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020003 symbiont-containing vacuole
Function GO:0003723 RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.30 0.85
Trophozoite expressed 1.10 0.47
Schizont possibly expressed 0.36 0.78
Gametocyte not expressed 0.16 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1135400

Resistome Missense Mutations: G216V

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 5 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.456 | MFS: -3.016 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II11

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.88) with 3CR3 (Global RMSD=18.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_205374

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 2
missense 0 0 0 0

PlasmoDB Total SNPs: 56

Non-coding: 37 | Synonymous: 14 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 245 | Molecular Weight (kDa): 28.496

UniProt ID(s): Q8II11

PDB ID(s): None

Isoelectric Point: 9.03

Protein Domain Annotations:

Source Family ID Description
InterPro IPR029069 HotDog domain superfamily
PFam N/A N/A
Superfamily SSF54637 HotDog domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28784333 Identification of novel parasitophorous vacuole proteins in P. falciparumparasites using BioID. Khosh-Naucke M, Becker J, ..., Spielmann T 10.1016/j.ijmm.2017.07.007
33906926 Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH Sinha A, Baumgarten S, ..., Scherf A 10.1128/mBio.00661-21