About Gene List

PF3D7_1135500

Genome location: Pf3D7_11_v3:1,387,091..1,388,909(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.24 0.85
Schizont possibly expressed 0.06 0.96
Gametocyte not expressed 0.40 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1135500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.49 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYI9

"Best" AlphaFill ligand hit: VYJ (11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6h-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Local RMSD=8.87) with 7LAZ (Global RMSD=16.56)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139444

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 18 10 22
disruptive 2 29 28 49
missense 2 28 24 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 35 15 26
disruptive 14 77 43 114
missense 6 66 38 66

PlasmoDB Total SNPs: 62

Non-coding: 45 | Synonymous: 12 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 44.071

UniProt ID(s): A0A143ZYI9

PDB ID(s): None

Isoelectric Point: 10.17

Protein Domain Annotations:

Source Family ID Description
InterPro IPR035979 RNA-binding domain superfamily
PFam N/A N/A
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21