Genome location: Pf3D7_11_v3:1,389,211..1,396,929(+)
Genome classification: Core
Product Description: condensin-2 complex subunit D3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000779 | condensed chromosome, centromeric region |
| Component | GO:0000796 | condensin complex |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
| Process | GO:0051304 | chromosome separation |
| Process | GO:0010032 | meiotic chromosome condensation |
| Process | GO:0007076 | mitotic chromosome condensation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | possibly expressed | 0.41 | 0.76 |
| Schizont | not expressed | 0.09 | 0.95 |
| Gametocyte | possibly expressed | 0.99 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1135600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.854 | #Insertions: 10
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0913000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0913000)
Modification: Disrupted | RMgm-2543
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II07
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=1.05) with 7K3Z (Global RMSD=22.67)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105753
Most Similar Human Ortholog: E9PLE0
TM-align score: 0.81 | RMSD: 2.69
Seq Identity: 0.23 | Length: 243 / 1818
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151503 | non-SMC condensin II complex subunit D3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 92 | 59 | 108 |
| disruptive | 39 | 227 | 94 | 260 |
| missense | 37 | 209 | 85 | 225 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 179 | 79 | 97 |
| disruptive | 86 | 417 | 186 | 395 |
| missense | 64 | 346 | 152 | 287 |
PlasmoDB Total SNPs: 249
Non-coding: 128 | Synonymous: 72 | Nonsynonymous: 48 | Stop Codon: 1
Protein Length: 1818 | Molecular Weight (kDa): 217.6
UniProt ID(s): Q8II07
PDB ID(s): None
Isoelectric Point: 8.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR026971 | Condensin subunit 1/Condensin-2 complex subunit D3 |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |