PF3D7_1135800

Genome location: Pf3D7_11_v3:1,397,248..1,398,391(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.18	0.89
Schizont	possibly expressed	0.04	0.97
Gametocyte	not expressed	0.28	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1135800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.123 | MFS: -2.718 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0912800)

Relative Growth Rate: 0.79 ± 0.15
Confidence: 5.14

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0912800)

Modification: Disrupted | RMgm-2542

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II06

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532541

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	11	10	11
disruptive	3	26	18	36
missense	3	26	16	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	24	7	15
disruptive	7	68	35	70
missense	7	58	26	37

PlasmoDB Total SNPs: 71

Non-coding: 45 | Synonymous: 21 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 159 | Molecular Weight (kDa): 19.13

UniProt ID(s): Q8II06

PDB ID(s): None

Isoelectric Point: 9.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A