PF3D7_1136100

Genome location: Pf3D7_11_v3:1,415,406..1,417,214(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MLNFSFLFFFSYAIFYKPYLC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	possibly expressed	0.13	0.92
Schizont	possibly expressed	0.03	0.99
Gametocyte	expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1136100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.778 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0912500)

Modification: Disrupted | RMgm-2539

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II03

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533696

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	31	15	41
disruptive	12	81	60	115
missense	12	78	59	110

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	62	18	48
disruptive	26	197	109	168
missense	23	176	101	128

PlasmoDB Total SNPs: 55

Non-coding: 1 | Synonymous: 33 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 602 | Molecular Weight (kDa): 72.21

UniProt ID(s): Q8II03

PDB ID(s): None

Isoelectric Point: 8.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A