PF3D7_1136400 (SRP72)

Genome location: Pf3D7_11_v3:1,426,876..1,431,677(-)

Genome classification: Core

Function and Localization

Product Description: signal recognition particle subunit SRP72, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005786	signal recognition particle, endoplasmic reticulum targeting
Function	GO:0008312	7S RNA binding
Function	GO:0005048	signal sequence binding
Process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.60	0.34
Trophozoite	expressed	1.13	0.43
Schizont	possibly expressed	0.77	0.56
Gametocyte	not expressed	0.70	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1136400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -2.91 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0912200)

Relative Growth Rate: 0.04 ± 0.07
Confidence: 6.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II00

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533175

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	44	27	51
disruptive	45	157	92	210
missense	26	135	73	175

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	84	43	63
disruptive	102	369	146	308
missense	57	289	123	176

PlasmoDB Total SNPs: 285

Non-coding: 137 | Synonymous: 79 | Nonsynonymous: 69 | Stop Codon: 0

Protein Information

Protein Length: 886 | Molecular Weight (kDa): 107.11

UniProt ID(s): Q8II00

PDB ID(s): None

Isoelectric Point: 8.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026270	Signal recognition particle, SRP72 subunit
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
24434517	Plasmodium falciparum signal recognition particle components and anti-parasiticeffect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP.	Panchal M, Rawat K, ..., Tuteja R	10.1038/cddis.2013.521