About Gene List

PF3D7_1136600 (MRST)

Genome location: Pf3D7_11_v3:1,440,742..1,445,784(+)

Genome classification: Core

Function and Localization

Product Description: modulator of ring stage translation MRST

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Process GO:0009410 response to xenobiotic stimulus
Process GO:0042254 ribosome biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.34 0.43
Trophozoite expressed 0.80 0.58
Schizont possibly expressed 0.36 0.80
Gametocyte possibly expressed 0.60 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1136600

Resistome Missense Mutations: S1088N

Resistome Compounds with Missense Mutations: GNF179/KAF179

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.986 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0912000)

Modification: Other | RMgm-429

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHZ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_200769

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 73 36 87
disruptive 89 298 153 322
missense 52 226 118 247

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 133 49 108
disruptive 169 533 204 405
missense 107 407 158 250

PlasmoDB Total SNPs: 335

Non-coding: 74 | Synonymous: 120 | Nonsynonymous: 141 | Stop Codon: 0

Protein Information

Protein Length: 1322 | Molecular Weight (kDa): 156.665

UniProt ID(s): Q8IHZ8

PDB ID(s): None

Isoelectric Point: 4.72

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
37219373 A novel Modulator of Ring Stage Translation (MRST) gene alters artemisininsensitivity in Plasmodium falciparum Simmons C, Gibbons J, ..., Adams JH 10.1128/msphere.00152-23