About Gene List

PF3D7_1136700 (AIP)

Genome location: Pf3D7_11_v3:1,446,063..1,449,550(+)

Genome classification: Core

Function and Localization

Product Description: armadillo-interacting protein AIP

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020008 rhoptry
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd nd
Trophozoite not expressed nd nd
Schizont expressed nd nd
Gametocyte not expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1136700.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.19 | MFS: -3.284 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0911900)

  • Relative Growth Rate: 0.10 ± nan
  • Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1E8

"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=18.23) with 4ZKE (Global RMSD=26.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533110

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 25 16 29
disruptive 2 18 19 74
missense 2 18 19 65

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 51 20 37
disruptive 4 82 44 111
missense 3 63 41 82

PlasmoDB Total SNPs: 159

Non-coding: 143 | Synonymous: 10 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 421 | Molecular Weight (kDa): 49.117

UniProt ID(s): Q8IHZ7

PDB ID(s): None

Isoelectric Point: 9.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
38391947 P. falciparum Invasion and Erythrocyte Aging Alves-Rosa MF, Tayler NM, ..., Spadafora C 10.3390/cells13040334