Product Description: DnaJ protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Function | GO:0030544 | Hsp70 protein binding |
| Process | GO:0071218 | cellular response to misfolded protein |
| Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
| Process | GO:0030433 | ubiquitin-dependent ERAD pathway |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.23 | 0.88 |
| Trophozoite | possibly expressed | 0.34 | 0.78 |
| Schizont | expressed | 0.23 | 0.84 |
| Gametocyte | not expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1136800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.149 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0911800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHZ6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101281
Most Similar Human Ortholog: F2Z2L8
TM-align score: 0.85 | RMSD: 1.09
Seq Identity: 0.27 | Length: 44 / 369
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148719 | DnaJ heat shock protein family (Hsp40) member B12 |
| ENSG00000164031 | DnaJ heat shock protein family (Hsp40) member B14 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 280
Non-coding: 266 | Synonymous: 6 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 369 | Molecular Weight (kDa): 44.528
UniProt ID(s): Q8IHZ6
PDB ID(s): None
Isoelectric Point: 9.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR018253 | DnaJ domain, conserved site |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |