PF3D7_1137100

Genome location: Pf3D7_11_v3:1,461,487..1,463,111(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S9, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005763	mitochondrial small ribosomal subunit
Component	GO:0015935	small ribosomal subunit
Function	GO:0003723	RNA binding
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.21	0.86
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.372 | MFS: -2.535 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0911600)

Relative Growth Rate: 0.08 ± 0.04
Confidence: 7.82

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHZ4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142584

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	14	10	28
disruptive	9	33	34	63
missense	9	32	33	57

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	33	13	23
disruptive	12	93	56	83
missense	10	81	48	60

PlasmoDB Total SNPs: 102

Non-coding: 72 | Synonymous: 15 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 300 | Molecular Weight (kDa): 35.363

UniProt ID(s): Q8IHZ4

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000754	Ribosomal protein S9
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
InterPro	IPR020574	Ribosomal protein S9, conserved site
PFam	PF00380	Ribosomal protein S9
Superfamily	SSF54211	Ribosomal protein S5 domain 2-type fold