About Gene List

PF3D7_1137200 (AEP)

Genome location: Pf3D7_11_v3:1,463,149..1,465,573(-)

Genome classification: Core

Function and Localization

Product Description: apical exonemal protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044311 exoneme

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite not expressed 0.13 0.93
Schizont expressed 0.99 0.52
Gametocyte possibly expressed 0.58 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.071 | #Insertions: 6

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0911500)

  • Relative Growth Rate: 0.84 ± 0.08
  • Confidence: 6.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0911500)

Modification: Disrupted | RMgm-2530

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHZ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171417

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 23 12 26
disruptive 8 46 38 78
missense 8 44 38 74

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 39 21 31
disruptive 15 119 64 96
missense 12 108 56 67

PlasmoDB Total SNPs: 108

Non-coding: 68 | Synonymous: 23 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 415 | Molecular Weight (kDa): 50.219

UniProt ID(s): Q8IHZ3

PDB ID(s): None

Isoelectric Point: 9.36

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
26431890 Identification and localization of a Novel Invasin of Plasmodium falciparum. Hans N, Relan U, ..., Chauhan VS 10.1016/j.molbiopara.2015.09.004