PF3D7_1137300

Genome location: Pf3D7_11_v3:1,465,889..1,469,381(-)

Genome classification: Core

Function and Localization

Product Description: CLPTM1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0012505	endomembrane system
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.13	0.50
Trophozoite	expressed	1.04	0.46
Schizont	expressed	0.28	0.82
Gametocyte	expressed	0.69	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.335 | #Insertions: 5

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0911400)

Relative Growth Rate: 0.73 ± 0.11
Confidence: 5.78

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0911400)

Modification: Disrupted | RMgm-2529

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHZ2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100901

Most Similar Human Ortholog: O96005

TM-align score: 0.70 | RMSD: 4.47

Seq Identity: 0.28 | Length: 548 / 689

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000049656	CLPTM1 like
ENSG00000104853	CLPTM1 regulator of GABA type A receptor forward trafficking
ENSG00000274811	CLPTM1 like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	36	22	57
disruptive	14	77	49	114
missense	8	67	46	98

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	76	36	48
disruptive	25	172	87	198
missense	13	142	79	129

PlasmoDB Total SNPs: 172

Non-coding: 102 | Synonymous: 44 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 689 | Molecular Weight (kDa): 81.607

UniProt ID(s): Q8IHZ2

PDB ID(s): None

Isoelectric Point: 9.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008429	Cleft lip and palate transmembrane 1
InterPro	IPR030434	Cleft lip and palate transmembrane protein 1-like protein
PFam	PF05602	Cleft lip and palate transmembrane 1
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094