About Gene List

PF3D7_1137400

Genome location: Pf3D7_11_v3:1,470,103..1,472,480(-)

Genome classification: Core

Function and Localization

Product Description: regulator of chromosome condensation, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.09 0.96
Trophozoite expressed 0.31 0.81
Schizont expressed 0.07 0.95
Gametocyte expressed 0.28 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -1.012 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0911300)

  • Relative Growth Rate: 0.53 ± 0.12
  • Confidence: 5.65

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0911300)

Modification: Disrupted | RMgm-2528

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHZ1

"Best" AlphaFill ligand hit: DXE (1,2-dimethoxyethane, Local RMSD=0.47) with 4X33 (Global RMSD=5.26)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122900

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 22 14 27
disruptive 4 12 21 46
missense 4 12 21 41

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 45 14 19
disruptive 6 58 47 88
missense 5 47 43 61

PlasmoDB Total SNPs: 156

Non-coding: 142 | Synonymous: 9 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 425 | Molecular Weight (kDa): 48.115

UniProt ID(s): Q8IHZ1

PDB ID(s): None

Isoelectric Point: 8.59

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFam PF00415 Regulator of chromosome condensation, RCC1
Superfamily SSF50985 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108