Product Description: ribosomal protein S14, apicoplast, putative
SignalP Peptide: MLSFIKLLLFFFNFMIFQG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.49 | 0.71 |
| Schizont | expressed | 0.41 | 0.75 |
| Gametocyte | expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1137500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.429 | MFS: -2.416 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0911200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHZ0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102116
Most Similar Human Ortholog: O60783
TM-align score: 0.70 | RMSD: 2.02
Seq Identity: 0.31 | Length: 100 / 172
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000120333 | mitochondrial ribosomal protein S14 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 6 | 14 |
| disruptive | 1 | 8 | 4 | 22 |
| missense | 1 | 8 | 3 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 26 | 9 | 13 |
| disruptive | 2 | 29 | 20 | 33 |
| missense | 2 | 19 | 14 | 23 |
PlasmoDB Total SNPs: 94
Non-coding: 88 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 172 | Molecular Weight (kDa): 20.926
UniProt ID(s): Q8IHZ0
PDB ID(s): None
Isoelectric Point: 10.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001209 | Ribosomal protein S14 |
| InterPro | IPR018271 | Ribosomal protein S14, conserved site |
| PFam | PF00253 | Ribosomal protein S14 |
| Superfamily | SSF57716 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |