About Gene List

PF3D7_1137600

Genome location: Pf3D7_11_v3:1,474,667..1,476,838(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 1.00
Trophozoite not expressed 0.01 0.99
Schizont not expressed 0.01 1.00
Gametocyte not expressed 0.37 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.448 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHY8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532799

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 34 26 34
disruptive 20 152 61 153
missense 13 128 52 125

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 79 20 40
disruptive 56 275 107 217
missense 34 231 71 135

PlasmoDB Total SNPs: 111

Non-coding: 24 | Synonymous: 61 | Nonsynonymous: 24 | Stop Codon: 2

Protein Information

Protein Length: 656 | Molecular Weight (kDa): 77.742

UniProt ID(s): Q8IHY8

PDB ID(s): None

Isoelectric Point: 7.62

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094