PF3D7_1137700

Genome location: Pf3D7_11_v3:1,477,643..1,479,850(+)

Genome classification: Core

Function and Localization

Product Description: calcium-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.10	0.94
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.44	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.586 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0911000)

Relative Growth Rate: 1.02 ± 0.18
Confidence: 4.81

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0911000)

Modification: Disrupted | RMgm-2526

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHY7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_175142

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	38	30	55
disruptive	16	106	66	148
missense	12	105	63	137

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	90	33	68
disruptive	29	240	106	218
missense	23	217	94	165

PlasmoDB Total SNPs: 56

Non-coding: 0 | Synonymous: 34 | Nonsynonymous: 19 | Stop Codon: 3

Protein Information

Protein Length: 735 | Molecular Weight (kDa): 88.292

UniProt ID(s): Q8IHY7

PDB ID(s): None

Isoelectric Point: 9.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand domain pair
PFam	PF13499	EF-hand domain
Superfamily	SSF47473	EF-hand domain pair