Genome location: Pf3D7_11_v3:1,480,900..1,481,526(-)
Genome classification: Core
Product Description: sporozoite surface protein essential for liver stage development, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Process | GO:0048469 | cell maturation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.06 | 0.96 |
| Trophozoite | no data | 0.00 | 1.00 |
| Schizont | no data | 0.03 | 0.98 |
| Gametocyte | no data | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1137800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.009 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0910900)
Modification: Tagged | RMgm-4073
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3F9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 4 | 10 |
| disruptive | 6 | 13 | 15 | 26 |
| missense | 6 | 13 | 13 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 20 | 7 | 20 |
| disruptive | 9 | 39 | 22 | 47 |
| missense | 7 | 34 | 20 | 36 |
PlasmoDB Total SNPs: 35
Non-coding: 23 | Synonymous: 3 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 151 | Molecular Weight (kDa): 17.899
UniProt ID(s): C6S3F9
PDB ID(s): None
Isoelectric Point: 8.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28067322 | A Novel and Conserved Plasmodium Sporozoite Membrane Protein SPELD is Requiredfor Maturation of Exo-erythrocytic Forms. | Al-Nihmi FM, Kolli SK, ..., Kumar KA | 10.1038/srep40407 |
| 28759593 | Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. | Swearingen KE, Lindner SE, ..., Mikolajczak SA | https://pubmed.ncbi.nlm.nih.gov/28759593/ |
| 34252120 | Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccineantigens using chimeric rodent parasites | Kolli SK, Salman AM, ..., Janse CJ | 10.1371/journal.pone.0254498 |
| 37703302 | Preliminary characterization of Plasmodium vivax sporozoite antigens aspre-erythrocytic vaccine candidates | Nicholas J, De SL, ..., Adams JH | 10.1371/journal.pntd.0011598 |