PF3D7_1137900

Genome location: Pf3D7_11_v3:1,483,375..1,485,858(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.36	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1137900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.85 | MFS: -3.024 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHY6

"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.07) with 4EGW (Global RMSD=38.61)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532584

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	38	23	57
disruptive	31	187	97	205
missense	28	182	95	193

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	74	43	60
disruptive	64	374	111	251
missense	54	343	105	185

PlasmoDB Total SNPs: 115

Non-coding: 44 | Synonymous: 30 | Nonsynonymous: 40 | Stop Codon: 1

Protein Information

Protein Length: 762 | Molecular Weight (kDa): 91.73

UniProt ID(s): Q8IHY6

PDB ID(s): None

Isoelectric Point: 8.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A