Genome location: Pf3D7_11_v3:1,496,635..1,498,092(+)
Genome classification: Core
Product Description: ubiquitin-related modifier 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0031386 | protein tag |
| Process | GO:0032447 | protein urmylation |
| Process | GO:0034227 | tRNA thio-modification |
| Process | GO:0002143 | tRNA wobble position uridine thiolation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.31 | 0.85 |
| Trophozoite | possibly expressed | 0.18 | 0.88 |
| Schizont | not expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.04 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1138100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.301 | MFS: -2.462 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHY3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102802
Most Similar Human Ortholog: Q9BTM9
TM-align score: 0.84 | RMSD: 1.61
Seq Identity: 0.34 | Length: 97 / 126
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000167118 | ubiquitin related modifier 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 65
Non-coding: 55 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 126 | Molecular Weight (kDa): 14.608
UniProt ID(s): Q8IHY3
PDB ID(s): None
Isoelectric Point: 4.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015221 | Ubiquitin-related modifier 1 |
| InterPro | IPR016155 | Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp |
| PFam | PF09138 | Ubiquitin-related modifier 1 |
| Superfamily | SSF54285 | Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 33022940 | Ubiquitin-Like Modifiers: Emerging Regulators of Protozoan Parasites | Karpiyevich M, Artavanis-Tsakonas K | 10.3390/biom10101403 |
| 37238603 | The Ubiquitin-like Proteins of Saccharomyces cerevisiae | Sengupta S, Pick E | 10.3390/biom13050734 |
| 35323018 | Involvement of Urm1, a Ubiquitin-Like Protein, in the Regulation of OxidativeStress Response of Toxoplasma gondii | Tan Q, Wang J, ..., Zhang X | 10.1128/spectrum.02394-21 |
| 36142209 | Uba1: A Potential Ubiquitin-like Activator Protein of Urm1 in Toxoplasma gondii | Xiao Q, Li J, ..., Zhang X | 10.3390/ijms231810298 |
| 32004955 | Redox requirements for ubiquitin-like urmylation of Ahp1, a 2-Cys peroxiredoxinfrom yeast | Brachmann C, Kaduhr L, ..., Schaffrath R | 10.1016/j.redox.2020.101438 |
| 34445460 | Role of SSD1 in Phenotypic Variation of Saccharomyces cerevisiae Strains LackingDEG1-Dependent Pseudouridylation | Khonsari B, Klassen R, Schaffrath R | 10.3390/ijms22168753 |
| 34782858 | Urm1, not quite a ubiquitin-like modifier? | Kaduhr L, Brachmann C, ..., Schaffrath R | 10.15698/mic2021.11.763 |