About Gene List

PF3D7_1138200

Genome location: Pf3D7_11_v3:1,498,115..1,499,068(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.01 1.00
Trophozoite expressed 0.01 0.99
Schizont expressed 0.02 0.99
Gametocyte expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1138200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.164 | MFS: -2.692 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHY2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149555

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 21 3 11
disruptive 1 15 7 20
missense 1 15 6 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 30 6 13
disruptive 5 20 19 46
missense 5 18 16 29

PlasmoDB Total SNPs: 52

Non-coding: 44 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 21.026

UniProt ID(s): Q8IHY2

PDB ID(s): None

Isoelectric Point: 7.91

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
22443220 Transcript and protein expression profile of PF11_0394, a Plasmodium falciparumprotein expressed in salivary gland sporozoites. Schlarman MS, Roberts RN, ..., Beerntsen BT 10.1186/1475-2875-11-80