PF3D7_1138300

Genome location: Pf3D7_11_v3:1,498,612..1,499,571(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.05	0.98
Trophozoite	no data	0.38	0.77
Schizont	no data	0.11	0.93
Gametocyte	no data	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1138300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.947 | MFS: -1.533 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3G0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105090

Most Similar Human Ortholog: Q69YG0

TM-align score: 0.71 | RMSD: 2.59

Seq Identity: 0.21 | Length: 120 / 144

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000169964	transmembrane protein 42
ENSG00000280516	transmembrane protein 42

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	4	7
disruptive	2	21	18	40
missense	2	18	18	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	16	7	14
disruptive	5	52	25	57
missense	4	43	22	40

PlasmoDB Total SNPs: 19

Non-coding: 6 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 144 | Molecular Weight (kDa): 17.144

UniProt ID(s): C6S3G0

PDB ID(s): None

Isoelectric Point: 10.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039632	Transmembrane protein 42
PFam	N/A	N/A
Superfamily	SSF103481	N/A