PF3D7_1138600

Genome location: Pf3D7_11_v3:1,521,810..1,524,748(-)

Genome classification: Core

Function and Localization

Product Description: beta-catenin-like protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005681	spliceosomal complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.23	0.89
Trophozoite	possibly expressed	0.58	0.66
Schizont	not expressed	0.13	0.92
Gametocyte	not expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1138600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.099 | #Insertions: 4

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0910100)

Relative Growth Rate: 0.42 ± 0.07
Confidence: 6.72

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0910100)

Modification: Disrupted | RMgm-2523

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHX9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102971

Most Similar Human Ortholog: A0A087WUB9

TM-align score: 0.84 | RMSD: 2.67

Seq Identity: 0.24 | Length: 483 / 527

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000132792	catenin beta like 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	36	27	41
disruptive	2	54	40	91
missense	1	54	38	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	79	17	37
disruptive	10	147	75	135
missense	3	127	65	103

PlasmoDB Total SNPs: 193

Non-coding: 146 | Synonymous: 40 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 527 | Molecular Weight (kDa): 62.419

UniProt ID(s): Q8IHX9

PDB ID(s): None

Isoelectric Point: 4.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013180	Beta-catenin-like protein 1, N-terminal
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR039678	Beta-catenin-like protein 1
PFam	PF08216	Beta-catenin-like protein 1, N-terminal
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094