Genome location: Pf3D7_11_v3:1,525,654..1,532,527(-)
Genome classification: Core
Product Description: protein KIC5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Process | GO:2001023 | regulation of response to drug |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 1.78 | 0.33 |
| Trophozoite | not expressed | 0.65 | 0.65 |
| Schizont | not expressed | 0.59 | 0.73 |
| Gametocyte | not expressed | 0.65 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1138700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.831 | MFS: -2.986 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHX8
"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.37) with 3MMR (Global RMSD=13.61)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 100 | 74 | 139 |
| disruptive | 51 | 330 | 175 | 421 |
| missense | 34 | 283 | 161 | 371 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 41 | 207 | 92 | 149 |
| disruptive | 123 | 663 | 254 | 510 |
| missense | 75 | 568 | 226 | 392 |
PlasmoDB Total SNPs: 244
Non-coding: 87 | Synonymous: 94 | Nonsynonymous: 63 | Stop Codon: 0
Protein Length: 1870 | Molecular Weight (kDa): 222.057
UniProt ID(s): Q8IHX8
PDB ID(s): None
Isoelectric Point: 9.55
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31896710 | A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malariaparasites. | Birnbaum J, Scharf S, ..., Spielmann T | 10.1126/science.aax4735 |
| 36624300 | Protein KIC5 is a novel regulator of artemisinin stress response in the malariaparasite Plasmodium falciparum | Simmons CF, Gibbons J, ..., Adams JH | 10.1038/s41598-023-27417-6 |