Product Description: WD repeat-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.63 | 0.70 |
| Trophozoite | possibly expressed | 0.76 | 0.58 |
| Schizont | expressed | 0.38 | 0.76 |
| Gametocyte | not expressed | 0.72 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1138800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -2.867 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHX6
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.74) with 4GM3 (Global RMSD=3.48)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102926
Most Similar Human Ortholog: Q15542
TM-align score: 0.60 | RMSD: 5.34
Seq Identity: 0.19 | Length: 577 / 1920
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148835 | TATA-box binding protein associated factor 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 109 | 57 | 121 |
| disruptive | 95 | 340 | 203 | 382 |
| missense | 54 | 284 | 168 | 315 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 224 | 68 | 157 |
| disruptive | 169 | 684 | 261 | 588 |
| missense | 109 | 561 | 204 | 408 |
PlasmoDB Total SNPs: 439
Non-coding: 183 | Synonymous: 143 | Nonsynonymous: 113 | Stop Codon: 0
Protein Length: 1920 | Molecular Weight (kDa): 222.078
UniProt ID(s): Q8IHX6
PDB ID(s): None
Isoelectric Point: 9.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| InterPro | IPR037264 | TFIID subunit TAF5, NTD2 domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF160897 | TFIID subunit TAF5, NTD2 domain superfamily |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |