PF3D7_1139100

Genome location: Pf3D7_11_v3:1,545,416..1,553,962(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005689	U12-type spliceosomal complex
Component	GO:0005730	nucleolus
Component	GO:0005681	spliceosomal complex
Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.06	0.55
Trophozoite	possibly expressed	0.49	0.73
Schizont	expressed	0.24	0.85
Gametocyte	not expressed	0.29	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1139100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.063 | #Insertions: 13

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0909800)

Modification: Disrupted | RMgm-4627

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHX4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122528

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	80	41	100
disruptive	101	319	142	356
missense	64	246	115	284

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	43	162	80	107
disruptive	181	651	299	734
missense	117	480	215	381

PlasmoDB Total SNPs: 448

Non-coding: 205 | Synonymous: 129 | Nonsynonymous: 110 | Stop Codon: 4

Protein Information

Protein Length: 1791 | Molecular Weight (kDa): 209.759

UniProt ID(s): Q8IHX4

PDB ID(s): None

Isoelectric Point: 5.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104