PF3D7_1139200

Genome location: Pf3D7_11_v3:1,553,848..1,555,709(-)

Genome classification: Core

Function and Localization

Product Description: VPS9 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.12	0.94
Trophozoite	possibly expressed	0.21	0.87
Schizont	possibly expressed	0.06	0.96
Gametocyte	not expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1139200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -3.221 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0909700)

Relative Growth Rate: 0.26 ± 0.20
Confidence: 4.60

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHX3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111225

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	7	25
disruptive	8	37	26	59
missense	8	36	26	57

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	30	22	28
disruptive	10	101	40	93
missense	10	89	34	70

PlasmoDB Total SNPs: 59

Non-coding: 39 | Synonymous: 9 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 383 | Molecular Weight (kDa): 45.424

UniProt ID(s): Q8IHX3

PDB ID(s): None

Isoelectric Point: 7.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003123	VPS9 domain
InterPro	IPR037191	VPS9 domain superfamily
PFam	PF02204	VPS9 domain
Superfamily	SSF109993	VPS9 domain superfamily