Genome location: Pf3D7_11_v3:1,556,447..1,565,469(-)
Genome classification: Core
Product Description: AP2 domain transcription factor AP2-G5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000792 | heterochromatin |
| Component | GO:0005634 | nucleus |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Function | GO:0005515 | protein binding |
| Function | GO:0043565 | sequence-specific DNA binding |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.80 | 0.67 |
| Trophozoite | not expressed | 1.10 | 0.47 |
| Schizont | not expressed | 0.31 | 0.82 |
| Gametocyte | not expressed | 1.31 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1139300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.777 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHX2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 155 | 75 | 177 |
| disruptive | 95 | 351 | 187 | 453 |
| missense | 61 | 297 | 166 | 380 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 63 | 288 | 105 | 198 |
| disruptive | 176 | 729 | 334 | 732 |
| missense | 107 | 590 | 291 | 526 |
PlasmoDB Total SNPs: 346
Non-coding: 119 | Synonymous: 134 | Nonsynonymous: 93 | Stop Codon: 0
Protein Length: 2653 | Molecular Weight (kDa): 309.443
PDB ID(s): None
Isoelectric Point: 6.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001471 | AP2/ERF domain |
| InterPro | IPR028078 | AP2-coincident, C-terminal domain |
| PFam | PF00847 | AP2/ERF domain |
| PFam | PF14733 | AP2-coincident, C-terminal domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21060817 | Identification and genome-wide prediction of DNA binding specificities for theApiAP2 family of regulators from the malaria parasite. | Campbell TL, De Silva EK, ..., Llinas M | 10.1371/journal.ppat.1001165 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33368818 | The PfAP2-G2 transcription factor is a critical regulator of gametocytematuration. | Singh S, Santos JM, ..., Llinas M | 10.1111/mmi.14676 |
| 34365503 | A cascade of transcriptional repression determines sexual commitment anddevelopment in Plasmodium falciparum. | Shang X, Shen S, ..., Zhang Q | 10.1093/nar/gkab683 |
| 35288749 | Genome-wide landscape of ApiAP2 transcription factors reveals aheterochromatin-associated regulatory network during Plasmodium falciparumblood-stage development. | Shang X, Wang C, ..., Zhang Q | 10.1093/nar/gkac176 |