PF3D7_1139800

Genome location: Pf3D7_11_v3:1,585,329..1,592,079(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.45	0.79
Trophozoite	expressed	1.22	0.41
Schizont	expressed	0.68	0.65
Gametocyte	not expressed	0.83	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1139800

Resistome Missense Mutations: L1050S

Resistome Compounds with Missense Mutations: DSM265

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.065 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0909200)

Relative Growth Rate: 0.05 ± 0.08
Confidence: 6.37

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHW8

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.56) with 2BVL (Global RMSD=27.05)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532439

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	110	65	164
disruptive	49	313	187	416
missense	38	286	173	380

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	249	100	155
disruptive	122	690	306	596
missense	79	586	276	471

PlasmoDB Total SNPs: 136

Non-coding: 10 | Synonymous: 51 | Nonsynonymous: 75 | Stop Codon: 0

Protein Information

Protein Length: 2213 | Molecular Weight (kDa): 265.265

UniProt ID(s): Q8IHW8

PDB ID(s): None

Isoelectric Point: 9.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A