PF3D7_1139900 (EMC8)

Genome location: Pf3D7_11_v3:1,593,266..1,595,319(+)

Genome classification: Core

Function and Localization

Product Description: ER membrane protein complex subunit 8, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0072546	EMC complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.25	0.88
Trophozoite	expressed	0.30	0.81
Schizont	expressed	0.06	0.96
Gametocyte	possibly expressed	0.23	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1139900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.198 | MFS: -2.836 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHW7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102725

Most Similar Human Ortholog: O43402

TM-align score: 0.87 | RMSD: 2.27

Seq Identity: 0.21 | Length: 192 / 198

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000100908	ER membrane protein complex subunit 9
ENSG00000131148	ER membrane protein complex subunit 8
ENSG00000285377	ER membrane protein complex subunit 9

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	10	4	13
disruptive	3	31	12	22
missense	3	30	11	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	21	9	16
disruptive	9	51	30	53
missense	5	50	25	33

PlasmoDB Total SNPs: 101

Non-coding: 93 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 198 | Molecular Weight (kDa): 23.233

UniProt ID(s): Q8IHW7

PDB ID(s): None

Isoelectric Point: 5.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005366	ER membrane protein complex subunit 8/9
PFam	PF03665	ER membrane protein complex subunit 8/9
Superfamily	N/A	N/A