Product Description: carbonic anhydrase
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 4.2.1.1 (Carbonic anhydrase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004089 | carbonate dehydratase activity |
| Function | GO:0016836 | hydro-lyase activity |
| Process | GO:0006730 | one-carbon metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.20 | 0.88 |
| Gametocyte | not expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1140000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 6 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.203 | MFS: -2.805 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0909000)
Modification: Disrupted | RMgm-834
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHW5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.2.1.1 | carbonic anhydrase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 33 | 27 | 57 |
| disruptive | 30 | 80 | 48 | 111 |
| missense | 26 | 75 | 45 | 97 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 88 | 31 | 69 |
| disruptive | 54 | 169 | 87 | 193 |
| missense | 42 | 143 | 73 | 131 |
PlasmoDB Total SNPs: 58
Non-coding: 8 | Synonymous: 27 | Nonsynonymous: 22 | Stop Codon: 1
Protein Length: 600 | Molecular Weight (kDa): 71.453
UniProt ID(s): Q8IHW5
PDB ID(s): None
Isoelectric Point: 9.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001148 | Alpha carbonic anhydrase domain |
| InterPro | IPR023561 | Carbonic anhydrase, alpha-class |
| InterPro | IPR036398 | Alpha carbonic anhydrase domain superfamily |
| PFam | PF00194 | Alpha carbonic anhydrase domain |
| Superfamily | SSF51069 | Alpha carbonic anhydrase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 25168745 | Discovery of a new family of carbonic anhydrases in the malaria pathogenPlasmodium falciparum--the eta-carbonic anhydrases. | Del Prete S, Vullo D, ..., Supuran CT | 10.1016/j.bmcl.2014.08.015 |