Product Description: V-type proton ATPase subunit F, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Component | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain |
| Function | GO:0042625 | ATPase-coupled ion transmembrane transporter activity |
| Function | GO:0046961 | proton-transporting ATPase activity, rotational mechanism |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
| Process | GO:0007035 | vacuolar acidification |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.03 | 0.98 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1140100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.831 | MFS: -2.068 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHW4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102324
Most Similar Human Ortholog: Q16864
TM-align score: 0.92 | RMSD: 1.44
Seq Identity: 0.43 | Length: 116 / 128
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000128524 | ATPase H+ transporting V1 subunit F |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 188
Non-coding: 184 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 128 | Molecular Weight (kDa): 14.624
UniProt ID(s): Q8IHW4
PDB ID(s): None
Isoelectric Point: 6.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005772 | ATPase, V1 complex, subunit F, eukaryotic |
| InterPro | IPR008218 | ATPase, V1 complex, subunit F |
| InterPro | IPR036906 | ATPase, V1 complex, subunit F superfamily |
| PFam | PF01990 | ATPase, V1 complex, subunit F |
| Superfamily | SSF159468 | ATPase, V1 complex, subunit F superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |