About Gene List

PF3D7_1140200

Genome location: Pf3D7_11_v3:1,600,448..1,603,560(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.29 0.87
Trophozoite expressed 1.39 0.35
Schizont expressed 1.08 0.46
Gametocyte possibly expressed 0.82 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1140200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.422 | MFS: -2.428 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0908800)

Modification: Disrupted | RMgm-2515

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHW3

"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=1.02) with 5V1T (Global RMSD=15.31)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533670

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 36 15 29
disruptive 68 186 55 140
missense 21 95 32 76

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 63 17 27
disruptive 142 278 93 161
missense 44 161 55 75

PlasmoDB Total SNPs: 262

Non-coding: 150 | Synonymous: 62 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 447 | Molecular Weight (kDa): 52.612

UniProt ID(s): Q8IHW3

PDB ID(s): None

Isoelectric Point: 4.12

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596