About Gene List

PF3D7_1140400

Genome location: Pf3D7_11_v3:1,607,519..1,608,723(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 1.00
Trophozoite possibly expressed 0.02 0.99
Schizont expressed 0.68 0.63
Gametocyte possibly expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1140400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.189 | MFS: -3.016 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0908600)

  • Relative Growth Rate: 0.99 ± 0.08
  • Confidence: 6.45

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0908600)

Modification: Disrupted | RMgm-2513

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHW1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179344

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 9 8 17
disruptive 4 9 11 20
missense 4 9 11 19

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 20 11 15
disruptive 6 27 22 43
missense 6 26 21 36

PlasmoDB Total SNPs: 54

Non-coding: 47 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 167 | Molecular Weight (kDa): 18.602

UniProt ID(s): Q8IHW1

PDB ID(s): None

Isoelectric Point: 5.48

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27714937 PlasmoSEP: Predicting surface-exposed proteins on the malaria parasite usingsemisupervised self-training and expert-annotated data. El-Manzalawy Y, Munoz EE, Lindner SE, Honavar V 10.1002/pmic.201600249