Genome location: Pf3D7_11_v3:1,610,100..1,615,809(+)
Genome classification: Core
Product Description: myosin K, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0015629 | actin cytoskeleton |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016459 | myosin complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0031982 | vesicle |
| Function | GO:0003779 | actin binding |
| Function | GO:0051015 | actin filament binding |
| Function | GO:0030898 | actin-dependent ATPase activity |
| Function | GO:0003774 | cytoskeletal motor activity |
| Function | GO:0000146 | microfilament motor activity |
| Process | GO:0007015 | actin filament organization |
| Process | GO:0030048 | actin filament-based movement |
| Process | GO:0007010 | cytoskeleton organization |
| Process | GO:0030050 | vesicle transport along actin filament |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.15 | 0.91 |
| Schizont | not expressed | 0.20 | 0.88 |
| Gametocyte | expressed | 0.96 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1140500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.507 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0908500)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0908500)
Modification: Tagged | RMgm-4667
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHW0
"Best" AlphaFill ligand hit: P15 (2,5,8,11,14,17-hexaoxanonadecan-19-ol, Local RMSD=0.06) with 6QDJ (Global RMSD=1.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 87 | 60 | 124 |
| disruptive | 50 | 186 | 121 | 279 |
| missense | 29 | 160 | 111 | 244 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 183 | 96 | 147 |
| disruptive | 92 | 401 | 216 | 410 |
| missense | 44 | 338 | 181 | 310 |
PlasmoDB Total SNPs: 256
Non-coding: 91 | Synonymous: 108 | Nonsynonymous: 57 | Stop Codon: 0
Protein Length: 1738 | Molecular Weight (kDa): 207.802
UniProt ID(s): Q8IHW0
PDB ID(s): None
Isoelectric Point: 9.69
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000048 | IQ motif, EF-hand binding site |
| InterPro | IPR001609 | Myosin head, motor domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00063 | Myosin head, motor domain |
| PFam | PF00612 | IQ motif, EF-hand binding site |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31283102 | Systematic analysis of Plasmodium myosins reveals differential expression,localisation, and function in invasive and proliferative parasite stages. | Wall RJ, Zeeshan M, ..., Tewari R | 10.1111/cmi.13082 |