PF3D7_1140600

Genome location: Pf3D7_11_v3:1,615,976..1,622,355(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.20	0.90
Trophozoite	not expressed	0.15	0.91
Schizont	expressed	0.89	0.57
Gametocyte	expressed	0.97	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1140600

Resistome Missense Mutations: H1276Q, H1276N

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.099 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0908400)

Modification: Disrupted | RMgm-2511

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHV9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533141

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	98	47	116
disruptive	57	269	158	377
missense	44	248	147	331

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	177	73	124
disruptive	136	576	261	507
missense	94	488	220	377

PlasmoDB Total SNPs: 278

Non-coding: 114 | Synonymous: 97 | Nonsynonymous: 67 | Stop Codon: 0

Protein Information

Protein Length: 1824 | Molecular Weight (kDa): 219.855

UniProt ID(s): Q8IHV9

PDB ID(s): None

Isoelectric Point: 10.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A