Genome location: Pf3D7_11_v3:1,622,360..1,632,547(-)
Genome classification: Core
Product Description: chromo domain-containing protein CDP
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Function | GO:0062072 | H3K9me3 modified histone binding |
| Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.23 | 0.48 |
| Trophozoite | expressed | 0.86 | 0.57 |
| Schizont | possibly expressed | 0.63 | 0.65 |
| Gametocyte | expressed | 0.82 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1140700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.141 | #Insertions: 11
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHV8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 89 | 59 | 141 |
| disruptive | 103 | 411 | 198 | 501 |
| missense | 64 | 332 | 167 | 405 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 195 | 96 | 138 |
| disruptive | 222 | 866 | 379 | 762 |
| missense | 130 | 666 | 278 | 412 |
PlasmoDB Total SNPs: 716
Non-coding: 209 | Synonymous: 253 | Nonsynonymous: 254 | Stop Codon: 0
Protein Length: 2275 | Molecular Weight (kDa): 267.963
UniProt ID(s): Q8IHV8
PDB ID(s): None
Isoelectric Point: 4.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000953 | Chromo/chromo shadow domain |
| InterPro | IPR016197 | Chromo-like domain superfamily |
| InterPro | IPR023779 | Chromo domain, conserved site |
| InterPro | IPR023780 | Chromo domain |
| PFam | PF00385 | Chromo domain |
| Superfamily | SSF54160 | Chromo-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 35460670 | Chromodomain Protein Interacts with H3K9me3 and Controls RBC Rosette Formation byRegulating the Expression of a Subset of RIFINs in the Malaria Parasite. | Sethumadhavan DV, Tiburcio M, ..., Rajavelu A | 10.1016/j.jmb.2022.167601 |